Endocrine Abstracts

Estrogens regulate bone growth and bone mass mainly via estrogen receptor-α (ERα). In addition, the anabolic effect of mechanical loading on cortical bone requires ERα. This lecture summarizes some recent findings characterizing the primary target cells and the crucial ERα domains for the mediation of these estrogenic effects on the skeleton.Mice with complete inactivation of ERα continue to grow throughout life associated with i...